Generalized Spatial Modulation in Large-Scale Multiuser MIMO Systems Generalized spatial modulation (GSM) uses nt transmit antenna elements but fewer transmit radio frequency (RF) chains, nrf. Spatial modulation (SM) and spatial multiplexing are special cases of GSMwith nrf = 1 and nrf = nt, respectively. In GSM, in addition to conveying information bits through nrf conventional modulation symbols (for example, QAM), the indices of the nrf active transmit antennas also convey information bits. In this paper, we investigate GSM for large-scale multiuser MIMO communications on the uplink. Our contributions in this paper include: 1) an average bit error probability (ABEP) analysis for maximum-likelihood detection in multiuser GSM-MIMO on the uplink, where we derive an upper bound on the ABEP, and 2) low-complexity algorithms for GSM-MIMO signal detection and channel estimation at the base station receiver based on message passing. The analytical upper bounds on the ABEP are found to be tight at moderate to high signal-to-noise ratios (SNR). The proposed receiver algorithms are found to scale very well in complexity while achieving near-optimal performance in large dimensions. Simulation results show that, for the same spectral efficiency, multiuser GSM-MIMO can outperform multiuser SM-MIMO as well as conventional multiuser MIMO, by about 2 to 9 dB at a bit error rate of 10-3. Such SNR gains in GSM-MIMO compared to SM-MIMO and conventional MIMO can be attributed to the fact that, because of a larger number of spatial index bits,GSM-MIMO can use a lower-order QAM alphabet which is more power efficient.